GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4699052 | 1 | rs4699055 | chr4:104154500 | CISD2 | chr4:103790135-103809913:+ | -0.15 | -3.6 | 0.000355 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs4699055 | chr4:104154500 | MANBA | chr4:103552644-103682151:- | 0.16 | 4.05 | 5.91E-5 | Testicular germ cell tumor |
| THCA | cis | rs470119 | 1 | rs470119 | chr22:50966914 | SCO2 | chr22:50961999-50964034:- | 0.15 | 5.03 | 6.96E-7 | Mean corpuscular hemoglobin |
| THCA | cis | rs470119 | 1 | rs470119 | chr22:50966914 | TYMP | chr22:50964184-50968514:- | -0.14 | -4.45 | 1.05E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6878284 | 1 | rs4703229 | chr5:101764856 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.62 | 3.21E-8 | Schizophrenia |
| THCA | cis | rs6878284 | 1 | rs4703232 | chr5:101811346 | SLCO4C1 | chr5:101569694-101632253:- | 0.24 | 5.56 | 4.4E-8 | Schizophrenia |
| THCA | cis | rs1577917 | 1 | rs4706254 | chr6:86602813 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -12.54 | 2.11E-31 | Response to antipsychotic treatment |
| THCA | cis | rs9346353 | 1 | rs4706273 | chr6:70391640 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.53 | 0.000462 | Sleep duration |
| THCA | cis | rs1577917 | 1 | rs4707239 | chr6:86610717 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -12.73 | 3.62E-32 | Response to antipsychotic treatment |
| THCA | cis | rs9346353 | 1 | rs4707289 | chr6:70391588 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.44 | 0.000643 | Sleep duration |
| THCA | cis | rs9346353 | 1 | rs4707343 | chr6:70457821 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.37 | 0.000799 | Sleep duration |
| THCA | cis | rs9346353 | 1 | rs4707392 | chr6:70513826 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.49 | 0.000531 | Sleep duration |
| THCA | cis | rs12216499 | 1 | rs4709248 | chr6:159355637 | RSPH3 | chr6:159398268-159421198:- | 0.24 | 5.01 | 7.65E-7 | Bladder cancer (smoking interaction) |
| THCA | cis | rs12216499 | 1 | rs4709251 | chr6:159380322 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs12216499 | 1 | rs4709252 | chr6:159380384 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |